| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38951710 |
A central player mediating this process is the Mis18 complex (Mis18α, Mis18β and Mis18BP1), which recruits the CENP-A-specific chaperone HJURP to centromeres for CENP-A deposition. Here, using a multi-pronged approach, we characterise the structure of the Mis18 complex and show that multiple hetero- and homo-oligomeric interfaces facilitate the hetero-octameric Mis18 complex assembly composed of 4 Mis18α, 2 Mis18β and 2 Mis18BP1. |
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4.0
OIP5
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