+ |
TP53 | down-regulates quantity by repression
transcriptional regulation
|
HR |
0.348 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255436 |
|
|
Homo sapiens |
|
pmid |
sentence |
15489903 |
P53 may downregulate HR through multiple mechanisms including the reported associations with the Rad51 and Rad54 recombinases, and the BLM and WRN helicases. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
HR |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273463 |
|
|
|
|
pmid |
sentence |
29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
Publications: |
1 |