Summary

Name NCK2
Full Name Cytoplasmic protein NCK2
Synonyms Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta | GRB4
Primary ID O43639
Links - -
Type protein
Relations 3
Function Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding NCK2 0.341
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK2 0.593
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK2 0.409
Publications: 1 Organism: Homo Sapiens