Summary

Name EGFR
Full Name Epidermal growth factor receptor
Synonyms Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 | ERBB, ERBB1, HER1
Primary ID P00533
Links - -
Type protein
Relations 210
Pathways EGFR, Glioblastoma Multiforme, Noonan syndrome, PI3K/AKT
Inhibitors VARLITINIB; OSI-420; tyrphostin B42; XL-647; CUDC-101; AV412; sapitinib; dacomitinib; tyrphostin AG 1478; afatinib; canertinib; lapatinib; neratinib; gefitinib; N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-propenamide; erlotinib; erlotinib hydrochloride; pelitinib; vandetanib; BMS-599626; WZ4002; 873837-23-1; PD-153035 hydrochloride
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.14
Publications: 7 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.14
Publications: 2 Organism: , Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.28
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.65
Publications: 12 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome, PI3K/AKT
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.37
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:EGFR, Noonan syndrome
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.51
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation EGFR 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome, PI3K/AKT
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.22
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation EGFR 0.35
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation EGFR 0.34
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation EGFR 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.59
Publications: 4 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation ERBB3 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV2 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EZR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS16 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLD2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STAM2 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.3
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSTP1 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.87
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome, PI3K/AKT
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PCNA 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CRK 0.28
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTNND1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB1 0.73
Publications: 5 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome, PI3K/AKT
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.73
Publications: 4 Organism: In Vitro, Homo Sapiens
Pathways:EGFR, Noonan syndrome, PI3K/AKT
+ up-regulates img/direct-activation.png phosphorylation HGS 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HGS 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: HeLa Cell
+ up-regulates img/direct-activation.png phosphorylation EZR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERRFI1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ img/unknown.png phosphorylation SCAMP3 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation RASA1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC6 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EPB41 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT5B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5B 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PKIA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EPS15 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.75
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding SHC2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png EGFR 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NCK1 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.36
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.48
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png binding STAT5A 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.91
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, PI3K/AKT
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png ubiquitination EGFR 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png binding EGFR 0.62
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIK3C2B 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.73
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, Noonan syndrome
+ up-regulates img/direct-activation.png binding EGFR 0.47
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png JAK2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding SHC1 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding EGFR
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation EGFR
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.65
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding NCK1 0.37
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.58
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.93
Publications: 2 Organism: Mus Musculus, In Vitro
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome, PI3K/AKT
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination EGFR 0.42
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding SHC3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.56
Publications: 1 Organism: Rattus Norvegicus
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.23
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/indirect-activation.png JAK1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT14 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EGFR 0.56
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.56
Publications: 1 Organism: In Vitro
Pathways:EGFR
+ up-regulates activity img/indirect-activation.png phosphorylation JAK1/STAT1/STAT3 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/indirect-activation.png MYC 0.22
Publications: 1 Organism: Mus Musculus
Tissue: Pancreas
Pathways:EGFR
+ up-regulates activity img/direct-activation.png binding EGFR 0.55
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.37
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:PI3K/AKT
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.91
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, PI3K/AKT
+ up-regulates img/direct-activation.png binding EGFR 0.56
Publications: 1 Organism: Homo Sapiens