3.0
Summary
| Name |  BNIP3L
|
| Full Name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
| Synonyms | Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L | BNIP3A, BNIP3H, NIX |
| Primary ID | O60238 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | HIF-1 complex | up-regulates quantity by expression 
transcriptional regulation
|
BNIP3L | 0.306 |
| Publications: | 1 | Organism: | Homo Sapiens | |