| + |
HIF-1 complex | up-regulates quantity 
transcriptional regulation
|
PDK1 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267480 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16517405 |
We found that HIF-1 also actively suppresses metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
LDHA |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673128 |
Deletional and mutational analysis of the function of mouse LDH-reporter fusion gene constructs in transient transfection assays defined three domains, between -41 and -84 base pairs upstream of the transcription initiation site, which were crucial for oxygen-regulated expression. The most important of these, although not capable of driving hypoxic induction in isolation, had the consensus of a hypoxia-inducible factor 1 (HIF-1) site, and cross-competed for the binding of HIF-1 with functionally active Epo and phosphoglycerate kinase-1 sequences |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
SLC2A1 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
HK1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
Hypoxia | up-regulates 
|
HIF-1 complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
Hypoxia-Inducible Factor-1 (HIF-1) is a key transcription factor that regulates gene expression under hypoxic conditions (Semenza, 2012, 2010a). HIF-1 consists of two subunits, HIF-1α and HIF-1β. While HIF-1β protein is constitutively expressed and present in excess, HIF-1α protein has a short half-life |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
PDK1 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16517405 |
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate. We found that HIF-1 also actively suppresses metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PK | up-regulates activity
binding
|
HIF-1 complex |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268150 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21620138 |
PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270311 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21620138 |
PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
VHL | down-regulates 
ubiquitination
|
HIF-1 complex |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80969 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944113 |
Here we show that the product of the von hippel-lindau (vhl) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of hif-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of hif-1 alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
Hexokinase |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
SLC2A1 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267478 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11120745 |
Collectively these results indicate that H-Ras up-regulates the glut1 promoter, at least in part, by increasing HIF-1alpha protein levels leading to transactivation of promoter through the HIF-1 binding site. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PKM | up-regulates activity
binding
|
HIF-1 complex |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267473 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21620138 |
PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
HK2 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
BNIP3 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
LDHB |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673128 |
Deletional and mutational analysis of the function of mouse LDH-reporter fusion gene constructs in transient transfection assays defined three domains, between -41 and -84 base pairs upstream of the transcription initiation site, which were crucial for oxygen-regulated expression. The most important of these, although not capable of driving hypoxic induction in isolation, had the consensus of a hypoxia-inducible factor 1 (HIF-1) site, and cross-competed for the binding of HIF-1 with functionally active Epo and phosphoglycerate kinase-1 sequences |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARNT | form complex 
binding
|
HIF-1 complex |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 consists of two subunits, HIF-1α and HIF-1β. While HIF-1β protein is constitutively expressed and present in excess, HIF-1α protein has a short half-life |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
SLC2A3 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | down-regulates quantity by repression
transcriptional regulation
|
BID |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | form complex
binding
|
HIF-1 complex |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 consists of two subunits, HIF-1α and HIF-1β. While HIF-1β protein is constitutively expressed and present in excess, HIF-1α protein has a short half-life |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
BNIP3L |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
PFKFB3 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267388 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11744734 |
PFKFB3, is highly induced by hypoxia and the hypoxia mimics cobalt and desferrioxamine. This induction could be replicated by the use of an inhibitor of the prolyl hydroxylase enzymes responsible for the von Hippel Lindau (VHL)-dependent destabilization and tagging of HIF-1α. The absolute dependence of the PFKFB3 gene on HIF-1 was confirmed by its overexpression in VHL-deficient cells and by the lack of hypoxic induction in mouse embryonic fibroblasts conditionally nullizygous for HIF-1α |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
Hexokinase |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267494 |
|
|
Homo sapiens |
Burkitt Lymphoma Cell Line |
| pmid |
sentence |
| 17785433 |
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
LDHA |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
3.0
HIF-1 complex
CPX-7381