3.0
Summary
| Name |  MED14
|
| Full Name | Mediator of RNA polymerase II transcription subunit 14 |
| Synonyms | Activator-recruited cofactor 150 kDa component, ARC150, Cofactor required for Sp1 transcriptional activation subunit 2, CRSP complex subunit 2, Mediator complex subunit 14, RGR1 homolog, hRGR1, Thyroid hormone receptor-associated protein complex 170 kDa component, Trap170, Transcriptional coactivator CRSP150, Vitamin D3 receptor-interacting protein complex 150 kDa component, DRIP150 | ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170 |
| Primary ID | O60244 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MED14 | form complex 
binding
|
Core mediator complex | 0.832 |
| Publications: | 1 | Organism: | Homo Sapiens | |