| + |
MED4 | form complex 
binding
|
Core mediator complex |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266675 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED24 | form complex
binding
|
Core mediator complex |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED25 | form complex
binding
|
Core mediator complex |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED26 | form complex
binding
|
Core mediator complex |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED29 | form complex
binding
|
Core mediator complex |
0.762 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED31 | form complex
binding
|
Core mediator complex |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED20 | form complex
binding
|
Core mediator complex |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED30 | form complex
binding
|
Core mediator complex |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CKM complex | down-regulates activity 
binding
|
Core mediator complex |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266687 |
|
|
in vitro |
|
| pmid |
sentence |
| 23563140 |
We found that interaction of the CKM with Mediator's middle module interferes with CTD-dependent RNAPII binding to a previously unknown middle-module CTD-binding site and with the holoenzyme formation process. Taken together, our results reveal the basis for CKM repression, clarify the origin of the connection between CKM subunits and the CTD and suggest that a combination of competitive interactions and conformational changes that facilitate holoenzyme formation underlie the mechanism of transcription regulation by Mediator. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MED23 | form complex
binding
|
Core mediator complex |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED27 | form complex
binding
|
Core mediator complex |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED17 | form complex
binding
|
Core mediator complex |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED19 | form complex
binding
|
Core mediator complex |
0.847 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED1 | form complex
binding
|
Core mediator complex |
0.804 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED22 | form complex
binding
|
Core mediator complex |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED8 | form complex
binding
|
Core mediator complex |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED28 | form complex
binding
|
Core mediator complex |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED9 | form complex
binding
|
Core mediator complex |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED6 | form complex
binding
|
Core mediator complex |
0.845 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED18 | form complex
binding
|
Core mediator complex |
0.877 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED21 | form complex
binding
|
Core mediator complex |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED11 | form complex
binding
|
Core mediator complex |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED15 | form complex
binding
|
Core mediator complex |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266660 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED14 | form complex
binding
|
Core mediator complex |
0.833 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED16 | form complex
binding
|
Core mediator complex |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Core mediator complex | up-regulates activity 
binding
|
RNA Polymerase II |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25693131 |
The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-coding RNA genes and is globally regulated by Mediator — a large, conformationally flexible protein complex with a variable subunit composition (for example, a four-subunit cyclin-dependent kinase 8 module can reversibly associate with it). Because of its direct and extensive interactions with Pol II, Mediator regulates multiple stages of Pol II transcription (for example, initiation and re-initiation). Mediator interactions with the super elongation complex (SEC) also seem to be important for its regulation of Pol II elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
MED7 | form complex
binding
|
Core mediator complex |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MED10 | form complex
binding
|
Core mediator complex |
0.845 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28467824 |
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase modules play regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Core mediator complex
CPX-3227