Summary

Name OPA1
Full Name Dynamin-like 120 kDa protein, mitochondrial
Synonyms Optic atrophy protein 1 | KIAA0567
Primary ID O60313
Links - -
Type protein
Relations 4
Pathways Mitochondrial dynamics in T cell exhaustion
Function Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png Mitochondrial_fusion 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OPA1 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage OPA1 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage OPA1 0.473
Publications: 1 Organism: Homo Sapiens