+ |
STOML2 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260379 |
|
|
Homo sapiens |
|
pmid |
sentence |
21746876 |
We performed real-time RT-PCR to measure the levels of PGC-1alpha mRNA and found that these were increased in SLP-2hi cells (Fig. 3h), supporting the idea that upregulation of SLP-2 expression is associated with an increase in the expression of mitochondrially targeted genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
binding
|
PLCG1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260378 |
|
|
Homo sapiens |
|
pmid |
sentence |
18641330 |
In these studies, we also found that SLP-2 interacted with Lck, ZAP70, LAT, and PLC-gamma1 during the 30-min period following stimulation in vitro|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signalling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates quantity by expression
transcriptional regulation
|
MFN2 |
0.343 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260380 |
|
|
Homo sapiens |
|
pmid |
sentence |
20359165 |
Of interest, induction of SLP-2 expression also resulted in significant increases in the levels of OPA-1 and mitofusin-2 (P < 0.05), both integral mitochondrial membrane proteins associated with mitochondrial fusion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
binding
|
CD3E |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260375 |
|
|
Homo sapiens |
JURKAT Cell |
pmid |
sentence |
18641330 |
We observed that SLP-2 steadily associated with the CD3-epsilon chain of the TCR complex under resting conditions and during the 60 min of stimulation|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signalling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
binding
|
LCK |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260376 |
|
|
Homo sapiens |
|
pmid |
sentence |
18641330 |
In these studies, we also found that SLP-2 interacted with Lck, ZAP70, LAT, and PLC-gamma1 during the 30-min period following stimulation in vitro|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signalling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
|
NDUFV1 |
0.289 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260382 |
|
|
Homo sapiens |
T-lymphocyte |
pmid |
sentence |
20359165 |
We found that SLP-2hi cells had significantly higher activities of NADH dehydrogenase and succinate dehydrogenase (P < 0.05), complexes I and II of the electron transport chain. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
|
SDHD |
0.21 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260383 |
|
|
Homo sapiens |
|
pmid |
sentence |
20359165 |
We found that SLP-2hi cells had significantly higher activities of NADH dehydrogenase and succinate dehydrogenase (P < 0.05), complexes I and II of the electron transport chain. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates activity
binding
|
ZAP70 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260377 |
|
|
Homo sapiens |
|
pmid |
sentence |
18641330 |
In these studies, we also found that SLP-2 interacted with Lck, ZAP70, LAT, and PLC-gamma1 during the 30-min period following stimulation in vitro|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signalling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates quantity by expression
transcriptional regulation
|
OPA1 |
0.318 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260381 |
|
|
Homo sapiens |
|
pmid |
sentence |
20359165 |
Of interest, induction of SLP-2 expression also resulted in significant increases in the levels of OPA-1 and mitofusin-2 (P < 0.05), both integral mitochondrial membrane proteins associated with mitochondrial fusion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STOML2 | up-regulates quantity
|
ATP |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260384 |
|
|
Homo sapiens |
|
pmid |
sentence |
20359165 |
In addition, mitochondrial and whole-cell ATP levels in resting SLP-2hi T cells were significantly higher than those in SLP-2lo T cells (P < 0.05) (Fig. 7d). Such an increase in ATP levels in SLP-2hi T cells correlated with increased resistance to depletion of mitochondrial ATP with oligomycin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |