Summary

Name STOML2
Full Name Stomatin-like protein 2, mitochondrial
Synonyms SLP-2, EPB72-like protein 2, Paraprotein target 7, Paratarg-7 | SLP2
Primary ID Q9UJZ1
Links - -
Type protein
Relations 10
Function Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARGC1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLCG1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MFN2 0.343
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CD3E 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LCK 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png NDUFV1 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SDHD 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OPA1 0.318
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png ATP 0.8
Publications: 1 Organism: Homo Sapiens