The SIGnaling Network
Open Resource

Pathway ID: SIGNOR-MD

Description: This pathway weaves together T cell activation pathways with regulators of mitochondrial dynamics (fission and fusion). It depicts the dynamic interplay between these molecular components, highlighting the orchestrated communication between T cell activation machinery and the regulation of mitochondrial morphology. The network's unique feature is its culmination, where specific nodes interacting with a tumor cell lead to the phenomenon of T cell exhaustion. This representation provides an insight into the molecular intricacies of T cell activation and mitochondrial dynamics unraveling the regulatory mechanisms triggering T cell exhaustion in response to tumor interactions.

Curated by: Hesham