| + |
SEMA3F | up-regulates 
binding
|
NRP2 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147608 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16816121 |
In the nervous system, neuropilins mediate axon retraction and guidance by binding class iii semaphorins. We found that sema3f could compete with metabolically labeled vegf-c for the binding to np1-ig and np2-ig fusion proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRP2 | up-regulates
binding
|
VEGFC |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147530 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16816121 |
By in vitro binding studies we found that both vegf-c and vegf-d interact with np2, vegf-c in a heparin-independent and vegf-d in a heparin-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEMA3B | up-regulates activity
binding
|
NRP2 |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261816 |
|
|
Homo sapiens |
Endothelial Cell, U-87MG Cell |
| pmid |
sentence |
| 25335892 |
Further examination of the composition of the functional Sema3B receptor revealed that, unlike Sema3A, which signals exclusively using the NP1 receptor, Sema3B utilizes both NP1 and NP2 for signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEMA3C | up-regulates
binding
|
NRP2 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147564 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16816121 |
Our experiments establish that small peptides containing the consensus decd sequence of sperm fertilinbeta bind specifically to an alpha6beta1 integrin receptor on the egg membrane. We conclude that fertilinbeta binds directly to the alpha6beta1 integrin on the egg surface and this partnership mediates sperm-egg fusion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEGFC | up-regulates
binding
|
NRP2 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147611 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16816121 |
The functional importance of the interaction of np2 with the lymphangiogenic growth factors was demonstrated by cointernalization of np2 along with vegfr-3 in endocytic vesicles of lymphatic endothelial cells upon stimulation with vegf-c or vegf-d. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NRP2
- 
- 