Relation Results

Summary

Name SEMA3C
Full Name Semaphorin-3C
Synonyms Semaphorin-E, Sema E | SEMAE
Primary ID Q99985
Links - -
Type protein
Relations 3
Function Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular developmen ...
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Type: Score: Layout: SPV 
0.5910.5080.402SEMA3CNRP2PLXNA2GATA6

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Relations
Regulator
Mechanism
target
score ℹ
+ SEMA3Cup-regulates img/direct-activation.png binding NRP2 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-147564 Homo sapiens Neuron
pmid sentence
Our experiments establish that small peptides containing the consensus decd sequence of sperm fertilinbeta bind specifically to an alpha6beta1 integrin receptor on the egg membrane. We conclude that fertilinbeta binds directly to the alpha6beta1 integrin on the egg surface and this partnership mediates sperm-egg fusion.
Publications: 1 Organism: Homo Sapiens
+ SEMA3Cup-regulates activity img/direct-activation.png binding PLXNA2 0.508
Identifier Residue Sequence Organism Cell Line
SIGNOR-253151
pmid sentence
Genes encoding the neurovascular guiding molecule semaphorin 3C (SEMA3C) and its receptor plexin A2 (PLXNA2) appear to be regulated directly by GATA6, and both GATA6 mutant proteins failed to transactivate these genes.
Publications: 1
+ GATA6up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SEMA3C 0.402
Identifier Residue Sequence Organism Cell Line
SIGNOR-253150
pmid sentence
Genes encoding the neurovascular guiding molecule semaphorin 3C (SEMA3C) and its receptor plexin A2 (PLXNA2) appear to be regulated directly by GATA6, and both GATA6 mutant proteins failed to transactivate these genes.
Publications: 1
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