| + |
NRP2 | up-regulates 
binding
|
VEGFC |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147530 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16816121 |
By in vitro binding studies we found that both vegf-c and vegf-d interact with np2, vegf-c in a heparin-independent and vegf-d in a heparin-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
bevacizumab | down-regulates activity 
binding
|
VEGFC |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259886 |
|
|
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 15961063 |
Clinical trials with VEGF inhibitors in a variety of malignancies are ongoing. Recently, a humanized anti-VEGF monoclonal antibody (bevacizumab; Avastin) has been approved by the FDA as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEGFC | up-regulates 
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252277 |
|
|
|
|
| pmid |
sentence |
| 17326328 |
More than a dozen different proteins have been identified as angiogenic activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, platelet-derived endothelial growth factor, granulocyte colony-stimulating factor, placental growth factor, interleukin-8, hepatocyte growth factor, and epidermal growth factor |
|
| Publications: |
1 |
| + |
VEGFC | up-regulates
binding
|
FLT4 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9435229 |
Vegf-c, was isolated as a ligand for the tyrosine kinase vegfr-3 (flt4) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Lung |
| + |
VEGFC | up-regulates
binding
|
NRP2 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147611 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16816121 |
The functional importance of the interaction of np2 with the lymphangiogenic growth factors was demonstrated by cointernalization of np2 along with vegfr-3 in endocytic vesicles of lymphatic endothelial cells upon stimulation with vegf-c or vegf-d. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEGFC | up-regulates
binding
|
KDR |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9435229 |
Vegf-c is also a ligand for vegfr-2 (12), but the functional significance of this potential interaction in vivo is unknown |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Lung |
| Pathways: | VEGF Signaling |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
VEGFC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255081 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
VEGFC
- 
- 