4.0
Summary
| Name |  ACSL4
|
| Full Name | Long-chain-fatty-acid--CoA ligase 4 |
| Synonyms | Long-chain acyl-CoA synthetase 4, LACS 4 | ACS4, FACL4, LACS4 |
| Primary ID | O60488 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | Ferroptosis in PDAC |
| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ACSL4 | up-regulates 
|
Ferroptosis | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | miR-3173-5p | down-regulates quantity by repression 
translation regulation
|
ACSL4 | |
| Publications: | 1 | Organism: | Homo Sapiens | |