Summary

Name LPXN
Full Name Leupaxin
Synonyms LPXN_HUMAN | LDLP
Primary ID O60711
Links - -
Type protein
Relations 1
Function Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation LPXN 0.388
Publications: 1 Organism: Homo Sapiens