Summary

Name LYN
Full Name Tyrosine-protein kinase Lyn
Synonyms Lck/Yes-related novel protein tyrosine kinase, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn | JTK8
Primary ID P07948
Links - -
Type protein
Relations 70
Pathways B-cell activation, EBV infection
Inhibitors ponatinib; Bafetinib
Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation LYN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation LYN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation LYN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GCSAM 0.249
Publications: 5 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation DAPP1 0.606
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RGS16 0.352
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation NMT1 0.354
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CD79A 0.728
Publications: 1 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation CD79B 0.664
Publications: 1 Organism: In Vitro
Pathways:B-cell activation
+ img/unknown.png phosphorylation HCLS1 0.7
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ACLY 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R8 0.316
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation WAS 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2B 0.443
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2A 0.588
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2C 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PAG1 0.712
Publications: 3 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation SLAMF1 0.307
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SLC4A1 0.343
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HCLS1 0.7
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP8 0.319
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.39
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EBV infection
+ down-regulates activity img/direct_inhibition.png dephosphorylation LYN 0.723
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation LYN 0.306
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation LYN 0.2
Publications: 1 Organism: In Vitro
Pathways:B-cell activation, EBV infection
+ down-regulates activity img/direct_inhibition.png dephosphorylation LYN 0.649
Publications: 2 Organism: Mus Musculus
+ img/unknown.png phosphorylation PDIA3 0.2
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CD19 0.765
Publications: 3 Organism: Mus Musculus
Pathways:B-cell activation, EBV infection
+ up-regulates img/direct-activation.png phosphorylation CD19 0.765
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, EBV infection
+ down-regulates activity img/direct_inhibition.png phosphorylation LYN 0.338
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LYN 0.512
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png phosphorylation PRKCD 0.533
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BTK 0.519
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation PTPN6 0.723
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKCD 0.533
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation LPXN 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.599
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation PLCG1 0.639
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.529
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Mk 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png binding LYN 0.765
Publications: 1 Organism: Mus Musculus
Pathways:B-cell activation, EBV infection
+ down-regulates activity img/direct_inhibition.png chemical inhibition LYN 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DOK3 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation PPP1R15A 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dl 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation CD22 0.734
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ down-regulates img/direct_inhibition.png chemical inhibition LYN 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LYN 0.436
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dk 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Ml 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation