Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262892 |
Tyr72 |
NIQELNVySEAQEPK |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17640867 |
Of a total of 11 tyrosine sites in LPXN, we mutated Tyr(22), Tyr(72), Tyr(198), and Tyr(257) to phenylalanine and demonstrated that LPXN was phosphorylated by Lyn only at Tyr(72) and that this tyrosine site is proximal to the LD3 domain. We further show that LPXN suppressed the secretion of interleukin-2 by BCR-activated A20 B cells and that this inhibition was abrogated in the Y72F LPXN mutant, indicating that the phosphorylation of Tyr(72) is critical for the biological function of LPXN. |
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