Summary

Name OPHN1
Full Name Oligophrenin-1
Synonyms OPHN1_HUMAN |
Primary ID O60890
Links - -
Type protein
Relations 5
Function Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ OPHN1up-regulates activity img/direct-activation.png gtpase-activating protein RHOA 0.618
Publications: 1 Organism: Homo Sapiens
+ OPHN1up-regulates img/indirect-activation.png F-actin_assembly 0.7
Publications: 1 Organism: Homo Sapiens
+ OPHN1up-regulates activity img/direct-activation.png gtpase-activating protein CDC42 0.619
Publications: 1 Organism: Homo Sapiens
+ NR1D1up-regulates activity img/direct-activation.png binding OPHN1 0.2
Publications: 1 Organism: Homo Sapiens
+ OPHN1up-regulates activity img/direct-activation.png gtpase-activating protein RAC1 0.569
Publications: 1 Organism: Homo Sapiens