Summary

Name TBL1X
Full Name F-box-like/WD repeat-containing protein TBL1X
Synonyms SMAP55, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked | TBL1
Primary ID O60907
Links - -
Type protein
Relations 2
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding SCF(TBL1) 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CTNNB1 0.643
Publications: 1 Organism: Homo Sapiens