4.0
Summary
| Name |  TBL1X
|
| Full Name | F-box-like/WD repeat-containing protein TBL1X |
| Synonyms | SMAP55, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked | TBL1 |
| Primary ID | O60907 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TBL1X | up-regulates activity 
binding
|
CTNNB1 | 0.659 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TBL1X | form complex 
binding
|
SCF(TBL1) | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-miR-610 | down-regulates quantity by repression 
post transcriptional regulation
|
TBL1X | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |