+ |
CSNK2A2 | up-regulates activity
phosphorylation
|
NOL3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262836 |
Thr149 |
SEAVQSGtPEEPEPE |
Homo sapiens |
|
pmid |
sentence |
12191471 |
Phosphorylation of ARC at T149 Is Required for Its Antiapoptotic Effect. Here we report that the function of ARC is regulated by protein kinase CK2. ARC at threonine 149 is phosphorylated by CK2. This phosphorylation targets ARC to mitochondria. ARC is able to bind to caspase-8 only when it is localized to mitochondria but not to the cytoplasm. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CSNK2A1 | up-regulates activity
phosphorylation
|
NOL3 |
0.327 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262837 |
Thr149 |
SEAVQSGtPEEPEPE |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
12191471 |
Phosphorylation of ARC at T149 Is Required for Its Antiapoptotic Effect. Here we report that the function of ARC is regulated by protein kinase CK2. ARC at threonine 149 is phosphorylated by CK2. This phosphorylation targets ARC to mitochondria. ARC is able to bind to caspase-8 only when it is localized to mitochondria but not to the cytoplasm. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
UBE3A | down-regulates quantity by destabilization
ubiquitination
|
NOL3 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278522 |
|
|
Homo sapiens |
|
pmid |
sentence |
20211139 |
Incubation of transfected HEK293T cells with the proteasome inhibitor, MG132 blocked Ube3A mediated degradation of Arc suggesting that Ube3A degrades Arc via the ubiquitin proteasome system .|The ubiquitination of Arc by Ube3A was confirmed by mass spectrometry which revealed that Ube3A catalyzed the polyubiquitination of Arc on Lysine 268 and 269 ( xref ). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |