Summary

Name PLXNA2
Full Name Plexin-A2
Synonyms Semaphorin receptor OCT | KIAA0463, OCT, PLXN2
Primary ID O75051
Links - -
Type protein
Relations 4
Function Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding PLXNA2 0.501
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLXNA2 0.248
Publications: 1
+ up-regulates img/direct-activation.png binding PLXNA2 0.853
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLXNA2 0.651
Publications: 1 Organism: Homo Sapiens