Summary

Name LRP4
Full Name Low-density lipoprotein receptor-related protein 4
Synonyms LRP-4, Multiple epidermal growth factor-like domains 7 | KIAA0816, LRP10, MEGF7
Primary ID O75096
Links - -
Type protein
Relations 3
Function Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ LRP4up-regulates activity img/direct-activation.png binding MUSK 0.72
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SDF2L1up-regulates activity img/direct-activation.png binding LRP4 0.2
Publications: 1 Organism: Homo Sapiens
+ AGRNup-regulates activity img/direct-activation.png binding LRP4 0.843
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle