Relation Results

Summary

Name MUSK
Full Name Muscle, skeletal receptor tyrosine-protein kinase
Synonyms Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
Primary ID O15146
Links - -
Type protein
Relations 11
Function Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the ...
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Type: Score: Layout: SPV 
0.7450.4680.4080.4680.20.7450.5590.719MUSKDOK7WNT11WNT9APDZRN3LRP4

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MUSKup-regulates activity img/direct-activation.png phosphorylation DOK7 0.745
Identifier Residue Sequence Organism Cell Line
SIGNOR-273845  Tyr395 CLPGTVEyQVPTSLR Mus musculus C2C12 Cell
pmid sentence
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273845 Tyr395 CLPGTVEyQVPTSLR Mus musculus
pmid sentence
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273846 Tyr405 PTSLRAHyDTPRSLC Mus musculus
pmid sentence
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes.
Publications: 3 Organism: Mus Musculus
+ WNT11up-regulates img/direct-activation.png binding MUSK 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-199641 Homo sapiens
pmid sentence
Musk has an extracellular region with homology to the frizzled crd,binding of which by wnt11 stimulates a pcp-like pathway during neuromuscolar development. Here, we show that in vivo, wnt11r and wnt4a initiate musk translocation from muscle membranes to recycling endosomes we provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase
Identifier Residue Sequence Organism Cell Line
SIGNOR-195966 Homo sapiens
pmid sentence
We provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase
Publications: 2 Organism: Homo Sapiens
+ WNT9Aup-regulates img/direct-activation.png binding MUSK 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-195975 Homo sapiens Neuron
pmid sentence
we provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ MUSKup-regulates img/direct-activation.png binding WNT11 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-199518 Homo sapiens
pmid sentence
Like ror, musk has an extracellular region with homolgogy to the frizzled crd, binding of which by wnt11 stimulates a pcp-like pathway during neuromuscular development
Publications: 1 Organism: Homo Sapiens
+ MUSKup-regulates activity img/direct-activation.png phosphorylation MUSK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273851 Homo sapiens
pmid sentence
AGRN is released by the nerve and binds to LRP4, which then binds to MuSK. This interaction leads to MuSK autophosphorylation and activation of its kinase function, leading to anterograde signalling by subsequent phosphorylation of DOK7 (not shown), which binds MuSK as a dimer.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ DOK7up-regulates img/direct-activation.png binding MUSK 0.745
Identifier Residue Sequence Organism Cell Line
SIGNOR-192264 Homo sapiens
pmid sentence
In addition, dok7, a cytoplasmic adaptor protein, is also required for musk activation in vivo. This review focuses on the physical interplay between these proteins and musk for activation and downstream signaling, which culminates in nmj formation.
Publications: 1 Organism: Homo Sapiens
+ PDZRN3down-regulates quantity img/direct_inhibition.png ubiquitination MUSK 0.559
Identifier Residue Sequence Organism Cell Line
SIGNOR-271664 Chlorocebus aethiops COS-7 Cell
pmid sentence
We have identified a PDZ domain containing RING finger 3 (PDZRN3) as a synapse-associated E3 ubiquitin ligase and have demonstrated that it regulates the surface expression of muscle-specific receptor tyrosine kinase (MuSK), the key organizer of postsynaptic development at the mammalian neuromuscular junction. PDZRN3 binds to MuSK and promotes its ubiquitination. Together, these data demonstrate that PDZRN3 is a catalytically active RING-type E3 ubiquitin ligase
Publications: 1 Organism: Chlorocebus Aethiops
+ LRP4up-regulates activity img/direct-activation.png binding MUSK 0.719
Identifier Residue Sequence Organism Cell Line
SIGNOR-273850 Homo sapiens
pmid sentence
AGRN is released by the nerve and binds to LRP4, which then binds to MuSK. This interaction leads to MuSK autophosphorylation and activation of its kinase function, leading to anterograde signalling by subsequent phosphorylation of DOK7 (not shown), which binds MuSK as a dimer.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
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