Summary

Name ATG13
Full Name Autophagy-related protein 13
Synonyms ATG13_HUMAN | KIAA0652
Primary ID O75143
Links - -
Type protein
Relations 8
Function Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

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Relations

Regulator Mechanism target score ℹ
+ ULK1up-regulates img/direct-activation.png phosphorylation ATG13 0.915
Publications: 1 Organism: Homo Sapiens
+ ATG13up-regulates img/direct-activation.png binding ULK2 0.741
Publications: 1 Organism: Homo Sapiens
+ ULK2up-regulates img/direct-activation.png phosphorylation ATG13 0.741
Publications: 1 Organism: Homo Sapiens
+ ATG13form complex img/form-complex.png binding ULK1/Atg13/Fip200 0.916
Publications: 1 Organism: Homo Sapiens
+ OFD1down-regulates quantity by destabilization img/direct_inhibition.png binding ATG13 0.2
Publications: 1 Organism: Homo Sapiens
+ ATG101up-regulates img/direct-activation.png binding ATG13 0.958
Publications: 1 Organism: Homo Sapiens
+ ATG13up-regulates img/direct-activation.png binding RB1CC1 0.917
Publications: 1 Organism: Homo Sapiens
+ MTORdown-regulates img/direct_inhibition.png phosphorylation ATG13 0.638
Publications: 1 Organism: Homo Sapiens