| + |
AMPK | up-regulates activity 
phosphorylation
|
ULK1/Atg13/Fip200 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209913 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
Under energy deprivation, AMPK positively regulates ULK1 to induce autophagy, with various studies revealing that AMPK binds to and phosphorylates ULK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
ULK1 | form complex 
binding
|
ULK1/Atg13/Fip200 |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
In mammals, two protein complexes, namely the ULK1-Atg13-FIP200 (200kDa focal adhesion kinase family-interacting protein) complex and the BeclinVps34 complex, function jointly to produce the phagophore membrane, the initial phase of autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RB1CC1 | form complex
binding
|
ULK1/Atg13/Fip200 |
0.914 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
In mammals, two protein complexes, namely the ULK1-Atg13-FIP200 (200kDa focal adhesion kinase family-interacting protein) complex and the BeclinVps34 complex, function jointly to produce the phagophore membrane, the initial phase of autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATG13 | form complex
binding
|
ULK1/Atg13/Fip200 |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
In mammals, two protein complexes, namely the ULK1-Atg13-FIP200 (200kDa focal adhesion kinase family-interacting protein) complex and the BeclinVps34 complex, function jointly to produce the phagophore membrane, the initial phase of autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C9orf72 | up-regulates activity
binding
|
ULK1/Atg13/Fip200 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261281 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27334615 |
C9orf72 interacts with the ULK1 initiation complex|C9orf72 regulates translocation of the ULK1 complex to the phagophore via Rab1a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OFD1 | down-regulates quantity by destabilization 
binding
|
ULK1/Atg13/Fip200 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34027042 |
We showed for the first time that the centrosomal protein OFD1, which is mutated in Oral-Facial-Digital type I syndrome, inhibits early phases of the LC3-mediated autop hagic cascade by acting as a receptor for unc-51-like kinase (ULK1) complex turnover. we demon strated that OFD1 is a novel autophagy receptor which selectively promotes the autophagic degradation of ATG13 via direct interaction with the C3/GABARAP family of proteins (Figure 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK1/Atg13/Fip200 | up-regulates activity
phosphorylation
|
AMBRA1 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219388 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20921139 |
When autophagy is induced, ulk1 phosphorylates ambra1, releasing the autophagy core complex from dynein. Its subsequent relocalization to the endoplasmic reticulum enables autophagosome nucleation. Ambra1-dlc1 dissociates from the dynein complex upon ulk1-dependent ambra1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Autophagy |
| + |
ULK1/Atg13/Fip200 | up-regulates 
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
In mammals, two protein complexes, namely the ULK1/Atg13/FIP200 (200kDa focal adhesion kinase family-interacting protein) complex and the Beclin/Vps34 complex, function jointly to produce the phagophore membrane, the initial phase of autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
RAB1A | up-regulates activity
binding
|
ULK1/Atg13/Fip200 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261283 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 27334615 |
Thus, these data show ULK1–Rab1a interaction in intact cells and reveal that this interaction is C9orf72 dependent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | down-regulates activity
phosphorylation
|
ULK1/Atg13/Fip200 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209904 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
Several studies published simultaneously illustrated that the equivalent mammalian ULK1Atg13FIP200 complex was also negatively regulated by mTORC1 in an analogous manner [17,18,24]. In mammalian cells, amino acid starvation or rapamycin treatment causes dephosphorylation of both Atg13 and ULK1, indicating that an mTORC1 input regulates the ULK1Atg13FIP200 complex mTORC1 modulates the kinase activity of ULK1 directly, with rapamycin treatment of cells leading to enhanced ULK1 kinase activity, whereas Rheb overexpression causes a decrease in ULK1 kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
ULK1/Atg13/Fip200 | down-regulates activity
phosphorylation
|
mTORC1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
Raptor phosphorylation by ULK1 was sufficient to completely block Rheb-induced mTORC1 activity in cells as well as mTORC1 kinase activity invitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
ULK1/Atg13/Fip200 | down-regulates activity
phosphorylation
|
AMPK |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209916 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21460634 |
Here we report that ulk1/2 in turn phosphorylates all three subunits of ampk and thereby negatively regulates its activity. Thus, we propose that ulk1 is not only involved in the induction of autophagy, but also in terminating signaling events that trigger autophagy. In our model, phosphorylation of ampk by ulk1 represents a negative feedback circuit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
3.0
ULK1/Atg13/Fip200