Summary

Name ULK1
Full Name Serine/threonine-protein kinase ULK1
Synonyms Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1 | KIAA0722
Primary ID O75385
Links - -
Type protein
Relations 52
Pathways MTOR Signaling
Function Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ULK1 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation ENO1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HK1 0.261
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATG9A 0.605
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FUNDC1 0.576
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SEC23B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ULK1 0.464
Publications: 7 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation ULK1 0.478
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DENND3 0.406
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation ULK1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation FBP1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PFKM 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ULK1 0.843
Publications: 3 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation ULK1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ULK1 0.547
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ULK1/Atg13/Fip200 0.913
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png ubiquitination ULK1 0.529
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ULK1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ULK1 0.403
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATG13 0.915
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization ULK1 0.552
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAG3 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination ULK1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RB1CC1 0.911
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GABARAP 0.663
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png binding ULK1 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ULK1 0.511
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPK 0.464
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png binding ULK1 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AMBRA1 0.682
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.478
Publications: 1 Organism: Homo Sapiens