Relation Results

Summary

Name ICOSLG
Full Name ICOS ligand
Synonyms B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1 | B7H2, B7RP1, ICOSL, KIAA0653
Primary ID O75144
Links - -
Type protein
Relations 3
Function Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces als ...
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Type: Score: Layout: SPV 
0.20.20.2PRKCBICOSLGPRKCAICOS

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCBup-regulates activity img/direct-activation.png phosphorylation ICOSLG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273797 Ser285 RDRCLQHsYAGAWAV Homo sapiens HeLa Cell
pmid sentence
PKCα and PKCβ are required for phosphorylation of ICOSL and ICOSL-mediated cytokine induction 
Publications: 1 Organism: Homo Sapiens
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation ICOSLG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273798 Ser285 RDRCLQHsYAGAWAV Homo sapiens HeLa Cell
pmid sentence
PKCα and PKCβ are required for phosphorylation of ICOSL and ICOSL-mediated cytokine induction. Therefore, S285 is required for PKC substrate (serine) phosphorylation of ICOSL, and each of the upstream arginines is similarly required for this phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ ICOSLGup-regulates activity img/direct-activation.png binding ICOS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272497 Homo sapiens
pmid sentence
ICOSL expression is largely restricted to professional antigen-presenting cells (APCs), including B cells [in which ICOSL is regulated by BAFFR and non-canonical NFκB signaling (20)], macrophages, and dendritic cells (DCs) (12, 17, 21, 22), but is also expressed by certain endothelial cells (23) and lung epithelium
Publications: 1 Organism: Homo Sapiens
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