Cullin-associated and neddylation-dissociated protein 2, Epididymis tissue protein Li 169, TBP-interacting protein of 120 kDa B, TBP-interacting protein 120B, p120 CAND2 | KIAA0667, TIP120B
Primary ID
O75155
Links
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Type
protein
Relations
2
Function
Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.
We show that KIAA10 indeed associates with 26 S proteasomes in mammalian cells but that this interaction is likely to depend on contacts with a subunit(s) besides S2/Rpn1. Most importantly, we provide strong evidence that TIP120B (TBP-interacting protein 120B (22)) is a specific substrate that is targeted for degradation in skeletal muscle through KIAA10-catalyzed polyubiquitination.