Summary

Name CNOT3
Full Name CCR4-NOT transcription complex subunit 3
Synonyms CCR4-associated factor 3, Leukocyte receptor cluster member 2 | KIAA0691, LENG2, NOT3
Primary ID O75175
Links - -
Type protein
Relations 3
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.

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Relations


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Regulator Mechanism target score ℹ
+ CNOT3form complex img/form-complex.png binding CCR4-NOT complex 0.827
Publications: 1 Organism: Homo Sapiens
+ CNOT3down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TNFRSF11A 0.2
Publications: 1 Organism: Mus Musculus
+ CNOT3