Summary

Name ATP6V1G1
Full Name V-type proton ATPase subunit G 1
Synonyms V-ATPase subunit G 1, V-ATPase 13 kDa subunit 1, Vacuolar proton pump subunit G 1, Vacuolar proton pump subunit M16 | ATP6G, ATP6G1, ATP6J
Primary ID O75348
Links - -
Type protein
Relations 1
Function Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png cleavage ATP6V1G1 0.2
Publications: 1 Organism: In Vitro