| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260264 |
|
|
in vitro |
|
| pmid |
sentence |
| 16226257 |
Cleavage of the V-ATPase G1 fusion protein by SARS-CoV 3CLpro was found in this study (Fig. 3), implying that 3CLpro potentially cleaves the cellular V-ATPase G1, and affects the function of vacuolar H(+)-ATPase. Meanwhile, a significant intracellular acidification has been demonstrated in the 3CLpro-expressing cells (Fig. 4D). The result correlated well with previous reports in that V-ATPase-specific inhibitors cause acidic pHi [28], [29], and influences cell apoptosis |
|
4.0
3C-like proteinase
- 
- 
cleavage