| + |
Elongin E3-Cul-5 | down-regulates quantity by destabilization 
polyubiquitination
|
FLNB |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271801 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19300455 |
Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteasomal degradation. Altogether, our results indicated that ASB2β can assemble with elongin B, elongin C, Cullin 5 and Rbx2 to reconstitute an active E3 ubiquitin ligase complex.ASB2β induces polyubiquitylation of FLNb. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ASB2 | down-regulates quantity by destabilization
binding
|
FLNB |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271795 |
|
|
|
|
| pmid |
sentence |
| 19300455 |
Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteasomal degradation. Altogether, our results indicated that ASB2β can assemble with elongin B, elongin C, Cullin 5 and Rbx2 to reconstitute an active E3 ubiquitin ligase complex.ASB2β induces polyubiquitylation of FLNb. |
|
| Publications: |
1 |
| + |
FBLIM1 | up-regulates activity 
binding
|
FLNB |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266106 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
FLNB
- 
- 