Relation Results

Summary

Name ASB2
Full Name Ankyrin repeat and SOCS box protein 2
Synonyms ASB-2 |
Primary ID Q96Q27
Links - -
Type protein
Relations 6
Function Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitinat ...
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Type: Score: Layout: SPV 
0.2660.2660.20.6340.4490.423MAPK3ASB2MAPK1ERK1/2Elongin E3-Cul-5FLNAFLNB

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK3up-regulates activity img/direct-activation.png phosphorylation ASB2 0.266
Identifier Residue Sequence Organism Cell Line
SIGNOR-272241 Ser371 RIRRSGVsPLHLAAE
pmid sentence
Indeed, using mass spectrometry, we showed for the first time that ASB2a is phosphorylated and that phosphorylation of serine-323 (Ser-323) of ASB2a is crucial for the targeting of the actin-binding protein filamin A (FLNa) to degradation. |Moreover, inhibition of the extracellular signal-regulated kinases 1 and 2 (Erk1/2) activity reduced ASB2a-mediated FLNa degradation.
Publications: 1
+ MAPK1up-regulates activity img/direct-activation.png phosphorylation ASB2 0.266
Identifier Residue Sequence Organism Cell Line
SIGNOR-272240 Ser371 RIRRSGVsPLHLAAE
pmid sentence
Indeed, using mass spectrometry, we showed for the first time that ASB2a is phosphorylated and that phosphorylation of serine-323 (Ser-323) of ASB2a is crucial for the targeting of the actin-binding protein filamin A (FLNa) to degradation. |Moreover, inhibition of the extracellular signal-regulated kinases 1 and 2 (Erk1/2) activity reduced ASB2a-mediated FLNa degradation.
Publications: 1
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ASB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272239 Ser371 RIRRSGVsPLHLAAE
pmid sentence
Indeed, using mass spectrometry, we showed for the first time that ASB2a is phosphorylated and that phosphorylation of serine-323 (Ser-323) of ASB2a is crucial for the targeting of the actin-binding protein filamin A (FLNa) to degradation. |Moreover, inhibition of the extracellular signal-regulated kinases 1 and 2 (Erk1/2) activity reduced ASB2a-mediated FLNa degradation.
Publications: 1
+ ASB2up-regulates activity img/direct-activation.png binding Elongin E3-Cul-5 0.634
Identifier Residue Sequence Organism Cell Line
SIGNOR-271800 Mus musculus C2C12 Cell
pmid sentence
Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteasomal degradation.  Altogether, our results indicated that ASB2β can assemble with elongin B, elongin C, Cullin 5 and Rbx2 to reconstitute an active E3 ubiquitin ligase complex.ASB2β induces polyubiquitylation of FLNb.
Publications: 1 Organism: Mus Musculus
+ ASB2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination FLNA 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-271740 Homo sapiens HeLa Cell
pmid sentence
ASB2 is the specificity subunit of an E3 ubiquitin ligase complex and is proposed to exert its effects by regulating the turnover of specific proteins; however, no ASB2 substrates had been identified. Here, we report that ASB2 targets the actin-binding proteins filamin A and B for proteasomal degradation. 
Publications: 1 Organism: Homo Sapiens
+ ASB2down-regulates quantity by destabilization img/direct_inhibition.png binding FLNB 0.423
Identifier Residue Sequence Organism Cell Line
SIGNOR-271795
pmid sentence
Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteasomal degradation.  Altogether, our results indicated that ASB2β can assemble with elongin B, elongin C, Cullin 5 and Rbx2 to reconstitute an active E3 ubiquitin ligase complex.ASB2β induces polyubiquitylation of FLNb.
Publications: 1
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