Relation Results

Name	GPR32
Full Name	Probable G protein-coupled receptor 32
Synonyms	\|
Primary ID	O75388
Links	- -
Type	protein
Relations	2
Function	G protein-coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions (PubMed:20080636). Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles (PubMed:26969756). Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor (PubMed:23462912). {ECO:0000269\|PubMed:20080636, ECO:0000269\|PubMed:23462912, ECO:0000269\|PubMed:26969756}.