| + |
DTD1 | up-regulates activity 
binding
|
CDC45 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273973 |
|
|
in vitro |
|
| pmid |
sentence |
| 25258324 |
The DNA unwinding element (DUE)-binding protein (DUE-B) binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator Cdc45 in vivo, and loads Cdc45 onto chromatin in Xenopus egg extracts. In egg extracts alanine mutation of the DUE-B C-terminal phosphorylation sites blocks Cdc45 loading and inhibits DNA replication. The effects of DUE-B C-terminal phosphorylation reveal a novel S phase kinase regulatory mechanism for Cdc45 loading and MCM helicase activation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CDC45 | up-regulates activity
binding
|
MCM |
0.952 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19614620 |
The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. Cdc45 interacts physically and functionally with the putative eukaryotic replicative DNA helicase, the MCM (mini-chromosome maintenance) complex, and forms a helicase active 'supercomplex', the CMG [Cdc45-MCM2-7-GINS (go-ichi-ni-san)] complex. These known protein-protein interactions, as well as unknown interactions and post-translational modifications, may be important for the regulation of Cdc45 and the initiation of DNA replication following DNA damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDC45
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