Relation Results

Summary

Name CDC45
Full Name Cell division control protein 45 homolog
Synonyms PORC-PI-1 | CDC45L, CDC45L2
Primary ID O75419
Links - -
Type protein
Relations 2
Function Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template D ...
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Type: Score: Layout: SPV 
0.9540.507CDC45MCMDTD1

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Relations
Regulator
Mechanism
target
score ℹ
+ CDC45up-regulates activity img/direct-activation.png binding MCM 0.954
Identifier Residue Sequence Organism Cell Line
SIGNOR-273974 Homo sapiens
pmid sentence
The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. Cdc45 interacts physically and functionally with the putative eukaryotic replicative DNA helicase, the MCM (mini-chromosome maintenance) complex, and forms a helicase active 'supercomplex', the CMG [Cdc45-MCM2-7-GINS (go-ichi-ni-san)] complex. These known protein-protein interactions, as well as unknown interactions and post-translational modifications, may be important for the regulation of Cdc45 and the initiation of DNA replication following DNA damage.
Publications: 1 Organism: Homo Sapiens
+ DTD1up-regulates activity img/direct-activation.png binding CDC45 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-273973 in vitro
pmid sentence
The DNA unwinding element (DUE)-binding protein (DUE-B) binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator Cdc45 in vivo, and loads Cdc45 onto chromatin in Xenopus egg extracts. In egg extracts alanine mutation of the DUE-B C-terminal phosphorylation sites blocks Cdc45 loading and inhibits DNA replication. The effects of DUE-B C-terminal phosphorylation reveal a novel S phase kinase regulatory mechanism for Cdc45 loading and MCM helicase activation.
Publications: 1 Organism: In Vitro
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