| + |
CDC45 | up-regulates activity 
binding
|
MCM |
0.954 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19614620 |
The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. Cdc45 interacts physically and functionally with the putative eukaryotic replicative DNA helicase, the MCM (mini-chromosome maintenance) complex, and forms a helicase active 'supercomplex', the CMG [Cdc45-MCM2-7-GINS (go-ichi-ni-san)] complex. These known protein-protein interactions, as well as unknown interactions and post-translational modifications, may be important for the regulation of Cdc45 and the initiation of DNA replication following DNA damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM7 | form complex 
binding
|
MCM |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM | up-regulates 
|
DNA_replication |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM6 | form complex
binding
|
MCM |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM3 | form complex
binding
|
MCM |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDT1 | up-regulates activity
binding
|
MCM |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261679 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14672932 |
Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin through the action of Cdc6 and Cdt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM4 | form complex
binding
|
MCM |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM2 | form complex
binding
|
MCM |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198428 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM5 | form complex
binding
|
MCM |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261675 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946136 |
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MCM
CPX-2940