3.0
Summary
| Name |  GMNNView Modifications |
| Full Name | Geminin |
| Synonyms | GEMI_HUMAN | |
| Primary ID | O75496 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AURKA | up-regulates activity 
phosphorylation
|
GMNN | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 | up-regulates activity
phosphorylation
|
GMNN | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GMNN | down-regulates activity 
binding
|
CDT1 | 0.972 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPOP | down-regulates activity
ubiquitination
|
GMNN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |