Summary

Name ABL1
Full Name Tyrosine-protein kinase ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150 | ABL, JTK7
Primary ID P00519
Links - -
Type protein
Relations 138
Pathways P38 Signaling and Myogenesis, Cell cycle: G2/M phase transition
Inhibitors imatinib methanesulfonate; bosutinib; imatinib; regorafenib; ponatinib; PD173955; AT9283; nocodazole; dasatinib (anhydrous); [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone; 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; DCC-2036; nilotinib
Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation, binding ABL1 0.58
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RAD52 0.3
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation NCK1 0.22
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LGALS3 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ROBO1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation PPARG 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRCIN1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PRKN 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation CDK5 0.22
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation WASF3 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PSMA7 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CASP9 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SPTLC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LASP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation WASL 0.14
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation WASL 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRK 0.44
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation BTK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAT 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAT 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYLK 0.28
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABL2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MDM2 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation RAD9A 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATR 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation RAD51 0.51
Publications: 3 Organism: Chlorocebus Aethiops, Mus Musculus
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation PSTPIP1 0.22
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation PSTPIP1 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation ABL1 0.14
Publications: 2 Organism: Chlorocebus Aethiops, Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation YAP1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ABL1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PRKD1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKD1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAPGEF1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD19 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RACK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN6 0.2
Publications: 3 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAD51 0.45
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation APBB1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN6 0.2
Publications: 2 Organism: In Vitro, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DDX5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDGFRB 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLSCR1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ERCC6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPX1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ABL1 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YTHDC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EPHB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRAP 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding ABL1 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CRKL 0.28
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MTOR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ABL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation DDB2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ABL1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RAD51 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation RIN1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation WRN 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ABL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding ABL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.14
Publications: 1 Organism: In Vitro