Relation Results

Summary

Name TNFRSF21
Full Name Tumor necrosis factor receptor superfamily member 21
Synonyms Death receptor 6 | DR6
Primary ID O75509
Links - -
Type protein
Relations 5
Pathways Multiple sclerosis
Function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release o ...
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Type: Score: Layout: SPV 
0.70.340.5870.7TNFRSF21ROSTNFTRADDDemyelination

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Relations
Regulator
Mechanism
target
score ℹ
+ TNFRSF21down-regulates img/indirect_inhibition.png ROS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263830 Homo sapiens
pmid sentence
Further, data from our laboratories indicate that selective agonism of TNFR2 rescues neurons from oxidative stress-induced cell death [160] and excitotoxic cell death [161, 162]. Similarly, TNFR2 activation induces expression of antiapoptotic and detoxifying proteins and protects OPCs against oxidative stress.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263831 Homo sapiens
pmid sentence
Further, data from our laboratories indicate that selective agonism of TNFR2 rescues neurons from oxidative stress-induced cell death [160] and excitotoxic cell death [161, 162]. Similarly, TNFR2 activation induces expression of antiapoptotic and detoxifying proteins and protects OPCs against oxidative stress.
Publications: 2 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ TNFup-regulates img/direct-activation.png binding TNFRSF21 0.34
Identifier Residue Sequence Organism Cell Line
SIGNOR-59745 Homo sapiens
pmid sentence
We report the identification and initial characterization of dr6, a new member of the tnf receptor family possessing a cytoplasmic death domain.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Multiple sclerosis
+ TNFRSF21up-regulates img/direct-activation.png binding TRADD 0.587
Identifier Residue Sequence Organism Cell Line
SIGNOR-100184 Homo sapiens
pmid sentence
Dr6 interacts with tradd
Publications: 1 Organism: Homo Sapiens
+ TNFRSF21down-regulates img/indirect_inhibition.png Demyelination 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263832 Homo sapiens
pmid sentence
Next to inhibition of sTNF/TNFR1 signaling, specific activation of TNFR2 may hold promise as a new MS therapy. Indeed, TNF promotes proliferation of oligodendrocyte progenitors and remyelination via TNFR2
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
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