| + |
calcium(2+) | up-regulates activity 
chemical activation
|
CIB2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35408910 |
Calcium- and integrin-binding protein 2 (CIB2) is a small EF-hand protein capable of binding Mg2+ and Ca2+ ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
magnesium(2+) | up-regulates activity
chemical activation
|
CIB2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35408910 |
Calcium- and integrin-binding protein 2 (CIB2) is a small EF-hand protein capable of binding Mg2+ and Ca2+ ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIB2 | up-regulates activity
binding
|
a7/b1 integrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35408910 |
So far, two integrins have been found to interact with CIB2: αIIbβ3 is expressed by platelets and megakaryocytes and, apparently, a common target for all CIB family members, at odds with α7Bβ1D, which seems to be CIB2-specific and is expressed in skeletal muscles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIB2 | up-regulates activity
binding
|
TMC2 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269665 |
|
|
Mus musculus |
Hair Cell |
| pmid |
sentence |
| 28663585 |
Furthermore, we report that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations. We conclude that calcium and integrin-binding protein 2 is required for normal operation of the mechanotransducer channels and is involved in limiting the growth of transducing stereocilia. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CIB2 | up-regulates activity
binding
|
TMC1 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269664 |
|
|
Mus musculus |
Hair Cell |
| pmid |
sentence |
| 28663585 |
Furthermore, we report that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations. We conclude that calcium and integrin-binding protein 2 is required for normal operation of the mechanotransducer channels and is involved in limiting the growth of transducing stereocilia. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CIB2 | up-regulates activity
binding
|
AIIB/b3 integrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35408910 |
So far, two integrins have been found to interact with CIB2: αIIbβ3 is expressed by platelets and megakaryocytes and, apparently, a common target for all CIB family members, at odds with α7Bβ1D, which seems to be CIB2-specific and is expressed in skeletal muscles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIB2 | down-regulates activity 
binding
|
mTORC1 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269663 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 34162842 |
Mechanistically, CIB2 negatively regulates mTORC1 by preferentially binding to 'nucleotide empty' or inactive GDP-loaded Rheb. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
CIB2
- 
- 