3.0
Summary
| Name |  PAK3View Modifications |
| Full Name | Serine/threonine-protein kinase PAK 3 |
| Synonyms | Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3 | OPHN3 |
| Primary ID | O75914 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PAK3 | down-regulates 
phosphorylation
|
TNNI3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | PAK3 |
phosphorylation
|
TNNI3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | PAK3 | up-regulates activity 
phosphorylation
|
PAK3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PAK3 | up-regulates
phosphorylation
|
RAF1 | 0.535 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAK3 | up-regulates activity
phosphorylation
|
SYN1 | 0.339 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | PAK3 | down-regulates
phosphorylation
|
CALD1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Smooth Muscle | |||
| + | PAK3 | down-regulates activity
phosphorylation
|
SORT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAK3 | up-regulates activity
phosphorylation
|
MYO6 | 0.341 |
| Publications: | 1 | Organism: | In Vitro | |