Summary

Name RAD17
Full Name Cell cycle checkpoint protein RAD17
Synonyms hRad17, RF-C/activator 1 homolog | R24L
Primary ID O75943
Links - -
Type protein
Relations 4
Function Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RAD17 0.853
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAD17 0.841
Publications: 2 Organism: Homo Sapiens