3.0
Summary
| Name |  NEURL1
|
| Full Name | E3 ubiquitin-protein ligase NEURL1 |
| Synonyms | Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, RING-type E3 ubiquitin transferase NEURL1 | NEURL, NEURL1A, RNF67 |
| Primary ID | O76050 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. |
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ubiquitination
polyubiquitination