Relation Results

Name	PDE9A
Full Name	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms	EC 3.1.4.35 \|
Primary ID	O76083
Links	- -
Type	protein
Relations	1
Function	Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). {ECO:0000250\|UniProtKB:Q8QZV1, ECO:0000269\|PubMed:18757755, ECO:0000269\|PubMed:21483814, ECO:0000269\|PubMed:25799991, ECO:0000269\|PubMed:9624146, ECO:0000305}.