Summary

Name SEC14L2
Full Name SEC14-like protein 2
Synonyms Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF | C22orf6, KIAA1186, KIAA1658
Primary ID O76054
Links - -
Type protein
Relations 3
Function Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SEC14L2 0.2
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SEC14L2 0.2
Publications: 1 Organism: In Vitro