Summary

Name PDE5A
Full Name cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE | PDE5
Primary ID O76074
Links - -
Type protein
Relations 5
Inhibitors icariin; sildenafil; tadalafil
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

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Relations

Regulator Mechanism target score ℹ
+ icariindown-regulates img/direct_inhibition.png chemical inhibition PDE5A 0.8
Publications: 1 Organism: Homo Sapiens
+ RHOBTB1down-regulates quantity by destabilization img/direct_inhibition.png binding PDE5A 0.2
Publications: 1 Organism: Homo Sapiens
+ Cullin 3-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PDE5A 0.2
Publications: 1 Organism: Homo Sapiens
+ sildenafildown-regulates activity img/direct_inhibition.png chemical inhibition PDE5A 0.8
Publications: 1 Organism: In Vitro
+ tadalafildown-regulates activity img/direct_inhibition.png chemical inhibition PDE5A 0.8
Publications: 1 Organism: Homo Sapiens