+ |
RHOBTB1 | down-regulates quantity by destabilization
binding
|
PDE5A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272312 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
30896450 |
RhoBTB1 augmented the cGMP response to nitric oxide by restraining the activity of phosphodiesterase 5 (PDE5) by acting as a substrate adaptor delivering PDE5 to the Cullin-3 E3 Ring ubiquitin ligase complex for ubiquitination inhibiting PDE5. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RHOBTB1 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.494 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272313 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
30896450 |
RhoBTB1 augmented the cGMP response to nitric oxide by restraining the activity of phosphodiesterase 5 (PDE5) by acting as a substrate adaptor delivering PDE5 to the Cullin-3 E3 Ring ubiquitin ligase complex for ubiquitination inhibiting PDE5. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |