3.0
Summary
| Name |  USP1View Modifications |
| Full Name | Ubiquitin carboxyl-terminal hydrolase 1 |
| Synonyms | Deubiquitinating enzyme 1, hUBP, Ubiquitin thioesterase 1, Ubiquitin-specific-processing protease 1 | |
| Primary ID | O94782 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | up-regulates activity 
phosphorylation
|
USP1 | 0.38 |
| Publications: | 1 | Organism: | In Vitro | |
| + | WDR48 | up-regulates activity
binding
|
USP1 | 0.945 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP1 | up-regulates quantity by stabilization
deubiquitination
|
DGCR8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP1 | down-regulates activity 
deubiquitination
|
FANCI | 0.654 |
| Publications: | 1 | |||
| + | USP1 | down-regulates activity
deubiquitination
|
FANCD2 | 0.753 |
| Publications: | 1 | Organism: | Homo Sapiens | |