+ |
ATM | up-regulates quantity by stabilization
phosphorylation
|
DGCR8 |
0.274 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277307 |
Ser677 |
RVGKQLAsQKILQLL |
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
34188037 |
Specifically, radiation-induced ATM-dependent phosphorylation of DGCR8 at serine 677 facilitates USP51 to bind, deubiquitinate, and stabilize DGCR8, which leads to the recruitment of DGCR8 and DGCR8's binding partner RNF168 to MDC1 and RNF8 at DSBs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ABL1 | up-regulates activity
phosphorylation
|
DGCR8 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262604 |
Tyr267 |
KRRTEEKyGGDSDHP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26126715 |
The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. When coexpressed in HEK293T cells, ABL phosphorylated DGCR8 at Tyr(267). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DGCR8 | up-regulates activity
binding
|
RNF168 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277309 |
|
|
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
34188037 |
Specifically, radiation-induced ATM-dependent phosphorylation of DGCR8 at serine 677 facilitates USP51 to bind, deubiquitinate, and stabilize DGCR8, which leads to the recruitment of DGCR8 and DGCR8's binding partner RNF168 to MDC1 and RNF8 at DSBs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP1 | up-regulates quantity by stabilization
deubiquitination
|
DGCR8 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277308 |
|
|
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
34188037 |
Specifically, radiation-induced ATM-dependent phosphorylation of DGCR8 at serine 677 facilitates USP51 to bind, deubiquitinate, and stabilize DGCR8, which leads to the recruitment of DGCR8 and DGCR8's binding partner RNF168 to MDC1 and RNF8 at DSBs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DGCR8 | form complex
binding
|
Microprocessor complex |
0.922 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264849 |
|
|
Homo sapiens |
HaCaT Cell |
pmid |
sentence |
24581491 |
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |